Document Type

Article

Department/Program

Virginia Institute of Marine Science

Publication Date

2016

Journal

PLOS ONE

Volume

11

Issue

5

Abstract

Oysters play an important role in estuarine and coastal marine habitats, where the majority of humans live. In these ecosystems, environmental degradation is substantial, and oysters must cope with highly dynamic and stressful environmental constraints during their lives in the intertidal zone. The availability of the genome sequence of the Pacific oyster Crassostrea gigas represents a unique opportunity for a comprehensive assessment of the signal transduction pathways that the species has developed to deal with this unique habitat. We performed an in silico analysis to identify, annotate and classify protein kinases in C. gigas, according to their kinase domain taxonomy classification, and compared with kinome already described in other animal species. The C. gigas kinome consists of 371 protein kinases, making it closely related to the sea urchin kinome, which has 353 protein kinases. The absence of gene redundancy in some groups of the C. gigas kinome may simplify functional studies of protein kinases. Through data mining of transcriptomes in C. gigas, we identified part of the kinome which may be central during development and may play a role in response to various environmental factors. Overall, this work contributes to a better understanding of key sensing pathways that may be central for adaptation to a highly dynamic marine environment.

DOI

10.1371/journal.pone.0155435

Keywords

ACTIVATED PROTEIN-KINASE; FACTOR-BETA SUPERFAMILY; LIGHT-CHAIN KINASE; CAENORHABDITIS-ELEGANS; TYROSINE KINASE; BIVALVE MOLLUSK; POSTTRANSLATIONAL MODIFICATIONS; DOPAMINERGIC-NEURONS; MOLECULAR-MECHANISMS; SIGNAL-TRANSDUCTION

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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