Date Thesis Awarded
7-2012
Access Type
Honors Thesis -- Access Restricted On-Campus Only
Degree Name
Bachelors of Science (BS)
Department
Chemistry
Advisor
Christopher J. Abelt
Committee Members
Jianjun Paul Tian
John C. Poutsma
Abstract
The goal of this study was to synthesize 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one, a PRODAN derivative, and perform fluorescence studies comparing the efficacy of various PRODAN derivatives as probes of solvent acidity in HSA. Fluorescence and absorption studies were performed to calculate relative quantum yields of probe-HSA complexes to free probe. Using the relationship between relative quantum yield and solvent acidity, the microacidity in HSA was extrapolated. 3-(dimethylamino)-8,9,10,11-tetrahydro-7H-cyclohepta[a] naphthalen -7-one was determined to be the optimal probe in this study.
Recommended Citation
Green, Amy Michele, "Synthesis of 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one as a Fluorescent Probe of Solvent Acidity in HSA" (2012). Undergraduate Honors Theses. William & Mary. Paper 527.
https://scholarworks.wm.edu/honorstheses/527
Creative Commons License
This work is licensed under a
Creative Commons Public Domain Dedication 1.0 License.
Comments
Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.