Date Thesis Awarded
5-2008
Access Type
Honors Thesis -- Access Restricted On-Campus Only
Degree Name
Bachelors of Science (BS)
Department
Chemistry
Advisor
Robert J. Hinkle
Committee Members
Christopher J. Abelt
Lisa M. Landino
Rene S. Cabral-Daniels
Abstract
Herein are described optimization studies on the first step of a one-pot, three-component reaction towards biologically active 2,6-disubstituted dihydropyrans (DHPs). Bismuth tribromide proves to be a satisfactory catalyst for a Mukaiyama aldol reaction between an aldehyde or ketone and a silylated enol ether or ketene acetal. This environmentally benign catalyst establishes the viability of a three-component, one-pot reaction toward DHP ring systems, present in anti-cancer, anti-fungal, and anti-osteoporosis agents, among others.
Recommended Citation
Katkish, Lauren, "Toward Biologically Active 2,6-Disubstituted Dihydropyran Ring Systems Using an Environmentally Benign Bismuth Catalyst and Mukaiyama Aldol Reaction" (2008). Undergraduate Honors Theses. William & Mary. Paper 841.
https://scholarworks.wm.edu/honorstheses/841
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Comments
Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.