Date Thesis Awarded

5-2011

Document Type

Honors Thesis

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Christopher J. Abelt

Committee Member

Lisa M. Landino

Committee Member

Christine Westberg

Abstract

The goal of study was to explore the synthesis of 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one. This molecule is designed to act as a fluorescent model for cholesterol. It mimics cholesterol in terms of size, shape, and hydrophobic nature. . A nine-step synthesis was explored in order to develop this model. 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one was designed to be used as a cholesterol model in order to explore the cholesterol binding sites of the protein human serum albumin.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Comments

Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.

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