Date Thesis Awarded

5-2009

Document Type

Honors Thesis

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Robert J. Hinkle

Committee Member

David W. Thompson

Committee Member

Lisa M. Landino

Committee Member

Matthew J. Wawersik

Abstract

BiBr3 and Bi(OTf)3 have proven to be effective catalysts for Mukaiyama aldol reactions and Intramolecular silyl-Modified Sakurai (ISMS)/silyl-Prins type reactions towards cis-2,6-disubstituted-3,4-dihydropyrans. Herein are described studies towards the use of these Bi(III) salts in multi-component reactions to afford cyclic ethers, a structural motif found in natural products, such as the diospongins, which have been reported to posses potential therapeutic value. These investigations have also attempted to shed light on the ambiguity surrounding the method of action behind Bi(III) salts' catalytic power.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Comments

Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.

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