Date Thesis Awarded
5-2009
Access Type
Honors Thesis -- Access Restricted On-Campus Only
Degree Name
Bachelors of Science (BS)
Department
Chemistry
Advisor
David E. Kranbuehl
Committee Members
Christopher J. Abelt
Carey Bagdassarian
Kim Whitley
Abstract
Previous studies in Dr. Kranbuehl's laboratory at the College of William and Mary have shown that carboxylic acids and amines react spontaneously to form amides. These results prompted questions about whether amino acids, which possess both carboxylic acid and amine functionality, would also spontaneously form amide bonds, creating peptides. For this study, aqueous amino acid solutions were created and placed in a 120 °C oven. Samples were taken over time and analyzed both quantitatively with a gas chromatograph mass spectrometer and qualitatively with an ion trap mass spectrometer. This dual analysis method allows for the measurement of amino acid concentration and the detection of small quantities of polypeptides.
Recommended Citation
Milam, Sarah Joan, "Spontaneous Amide Bond Formation of Amino Acids in Aqueous Solution" (2009). Undergraduate Honors Theses. William & Mary. Paper 286.
https://scholarworks.wm.edu/honorstheses/286
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Comments
Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.