Date Thesis Awarded

4-2015

Document Type

Honors Thesis

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Jonathan Scheerer

Committee Member

Harmony Dalgleish

Committee Member

Elizabeth Harbron

Committee Member

Robert Hinkle

Abstract

This thesis outlines progress towards the synthesis of aristopyridinone A. Aristopyridinone A is a compound isolated from the traditional Chinese medicine plant Aristolochia manshuriensis. While the plant has been used in a variety of medicinal capacities, the biological activity of aristopyridinone A is unknown. The synthetic pathways presented in this thesis expand on previous work using a merged Diels Alder [4+2] cycloaddition and cycloreversion strategy to form the 2-pyridone core of the aristopyridinone A molecule. These studies also explore the chemistry of the inter-molecular Diels-Alder reaction using a diketopiperazine-derived azadiene.

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